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Frequently Asked Questions

What is brimonidine (Alphagan, Alphagan P) used for?

Short Answer

It is an eye drop used to reduce pressure within the eye.

Long Answer

Brimonidine (bri MO ni deen) ophthalmic solution, sold as (Alphagan, Alphagan-P), is an eye drop that is used to treat conditions such as ocular hypertension or open-angle glaucoma.

Additional Information

Drugs.com: Alphagan P
What is Alphagan P (brimonidine ophthalmic)? Brimonidine reduces the amount of fluid in the eye, which decreases pressure inside the eye. Brimonidine ophthalmic is used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye). Brimonidine ophthalmic may also be used for other purposes not listed in this medication guide.

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Seek emergency medical attention if you think you have used too much of this medicine, or if anyone has accidentally swallowed it. An overdose of brimonidine ophthalmic is unlikely to cause life-threatening side effects.
Wikipedia: Brimonidine
Brimonidine (bri-MOE-ni-deen, brand names Alphagan and Alphagan-P) is a drug used to treat open-angle glaucoma or ocular hypertension. Alphagan is also used to induce miosis for people suffering from poor night vision after Lasik or PRK surgery.
It acts via decreasing synthesis of aqueous humor, and increasing the amount that drains from the eye. As a treatment for glaucoma, it is usually given in eyedrop form. Brimonidine is an a2-adrenergic receptor agonist.
Alpha 2 agonists, through the activation of the Gi GPCR, inhibit the activity of adenylate cyclase. This reduces cAMP and hence aqueous humour production by the ciliary body.
NetDoctor.co.uk: Alphagan (brimonidine)
Alphagan eye drops contain the active ingredient brimonidine, which is a type of medicine called an alpha agonist. It works by stimulating alpha receptors found on blood vessels in the eye.
The pressure within the eyeball is naturally maintained by a continuous flow of liquid called aqueous humour through the eyeball. Aqueous humour is produced by a part of the eye called the ciliary body. It drains out of the eyeball through channels called the trabecular meshwork. If the outflow of aqueous humour is blocked, as in glaucoma, the aqueous humour builds up inside the eye, increasing the pressure within the eyeball. This pressure needs to be reduced, as otherwise it can damage the optic nerve and impair vision as a result.
Brimonidine stimulates alpha receptors found on the blood vessels that supply the ciliary body. This causes the blood vessels to constrict, and reduces the amount of watery fluid that filters out of the blood vessels to form aqueous humour. Brimonidine therefore works by reducing the inflow of aqueous humour into the eyeball, which decreases the pressure within the eye. It is used to treat conditions where there is raised pressure in the eye, such as glaucoma.
Brimonidine eye drops are used to treat glaucoma in people who cannot use beta-blocker eye drops. They may also be used in conjunction with other types of eye drop, for example beta-blockers or prostglandin analogues, to treat glaucoma in people whose eye pressure has not been lowered sufficiently with one medicine.
Eye drops are used to produce a local effect in the eye, with minimal effect on other parts of the body. You can further minimise the amount of medicine that is absorbed into your bloodstream and increase the local action in the eye by pressing on your tear duct (the corner of the eye closest to the nose) while putting in the eye drops and for a minute after.
Medication Information on eMedicineHealth: Alphagan P
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