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River Pharmacy - Your Neighborhood Drugstore Online

Frequently Asked Questions

Will Sibutramine (Meridia) by itself help me lose weight?

Short Answer

For best results, you should follow a nutritious eating plan combined with an exercise program while taking sibutramine (si-BYOO-tra-meen) under the supervision of your doctor.

Long Answer

This medication is usually formulated as sibutramide hydrochloride monohydrate and marketed as Meridia, Ectiva, and Reduxade in the USA and Reductil in Europe. As a serotonin-noradrenaline (norepinephrine) reuptake inhibitor, the drug works by affecting natural chemicals in the brain involved in regulating appetite. Meridia is the only reuptake inhibitor indicated for the management of obesity as of this writing.

Meridia must never be taken within 14 days of using a Monoamine Oxidase (MAO) Inhibitor such as Marplan, Nardil, or Parnate used to relieve certain types of mental depression or Parkinson's Disease. The combination could lead to serious, even fatal, overstimulation.

Sibutramine may also interact with a wide variety of other prescription and over-the-counter drugs, especially weight-reducing agents, decongestants, antidepressants, allergy medications, and cough and cold remedies that contain ephedrine or pseudoephedrine. Check with your doctor if you are taking sibutramine and are taking any of the following:

  • Alcohol (excessive amounts)
  • Appetite suppressants, other (benzphetamine/Didrex, diethylpropion/Tenuate, mazindol/Sanorex, phendimetrazine/Phendiet, phentermine/Ionamin]).
  • Blood thinners (Warfarin/Coumadin)
  • Bromocriptine (Parlodel)
  • Buspirone (BuSpar)
  • Certain tricyclic antidepressants (amitriptyline/Elavil, clomipramine/Anafranil, imipramine/Tofranil])
  • Dextromethorphan (cough medicine)
  • Dihydroergotamine (D.H.E. Injection, Migranal Nasal Spray)
  • Drugs that affect platelet function
  • Erythromycin (Eryc, Ery-Tab, PCE)
  • Fentanyl (Duragesic)
  • Fluoxetine (Prozac)
  • Fluvoxamine (Luvox)
  • Ketoconazole (Nizoral)
  • Levodopa (Sinemet)
  • Lithium (Eskalith)
  • Lithium (Eskalith, Lithobid)
  • Meperidine (Demerol)
  • Meperidine (Demerol)
  • Moclobemide (Manerex).
  • Monoamine oxidase (MAO) inhibitor activity (isocarboxazid/Marplan, phenelzine/Nardil, procarbazine/Matulane, selegiline/Eldepryl, tranylcypromine/Parnate])
  • Naratriptan (Amerge)
  • Nefazodone (Serzone)
  • Paroxetine (Paxil)
  • Pentazocine (Talwin NX, Talacen)
  • Selective serotonin reuptake inhibitors (citalopram/Celexa, fluoxetine/Prozac, fluvoxamine/Luvox, paroxetine/Paxil, sertraline/Zoloft])
  • Stimulants such as amphetamines, Dexedrine, Desoxyn, Adderall, Didrex, and Ionamin
  • Street drugs (LSD, MDMA/ecstasy, marijuana)
  • Sumatriptan (Imitrex)
  • Tramadol (Ultram)
  • Trazodone (Desyrel)
  • Tryptophan (L-Tryptophan)
  • Venlafaxine (Effexor)
  • Zolmitriptan (Zomig)

Follow your doctor's advice while taking this or any other obesity treatment.

Additional Information